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KMID : 0358619960300010001
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Korean Journal of Physiology
1996 Volume.30 No. 1 p.1 ~ p.9
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Effects of Adenosine on the Ionic Channel Activated by Metabolic Inhibition in Rabbit Ventricular Myocytes
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Han Jin
Kim Eui-Yong
Ho Won-Kyung
Earm Yung-E
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Abstract
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The objective of the present study was to characterize the role of adenosine in regulation of ATP-sensitive activity in isolated rabbit ventricular myocytes using the patch clamp technique. Internal adenosine had little effects on KaTr channel activity. In an outside-out patch with intrapipette GTP and ATP, external adenosine stimulated activity. In an inside-out Patch with intrapipette adenosine, ATP reduced activity, and GTP stimulated activity. Adenosine receptor activation shifted the half-maximal inhibition Of . These results Suggest that activation of adenosine receptors stimulates in rabbit ventricular myocytes by reducing the apparent affinity of the channel for ATP. The effect may be important for activating during early phase of myocardial ischemia.
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KEYWORD
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Adenosine, ATP-sensitive channel, Inside-out patch, Outside-out patch, Myocardial ischemia
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